According to European Pharmacopoeia (EP) Chapter 4 (4.1.1)

Reagecon's Dimidium Bromide - Sulphan Blue Mixed Solution is a high quality Indicator Solution produced from the highest quality raw materials and manufactured and tested under rigorous conditions. For manual titrations; indicator titrant or analyte change colour and this colour change is by far the most important method of end point detection, in such titrations. A high quality indicator solution such as Reagecon's facilitates end point detection, in a clear and unambiguous manner and is an imperative for accurate manual titrimetry.